# PocketGull Clinical Intelligence & Case Studies Commons
> Evidence-grounded systems biology, real-world case studies, and transparent retail pharmacy benchmarks.

PocketGull LLC provides actionable clinical intelligence, de-identified real-world case studies, and open HL7 FHIR R4 interoperability schemas. All clinical models adhere to the Three Acts Framework (Bridge, Pacing, Stepped-Care Resilience), HIPAA §164.514 Safe Harbor de-identification, and FDA §520(o) non-device clinical decision support boundaries.

## Canonical Clinical Case Studies
- [Cardiometabolic & Glycemic Radar](https://pocketgull.com/case-studies/cardiometabolic-radar): Postprandial glucose velocity (dG/dt), insulin-independent GLUT4 translocation, soleus muscle pump pacing (Hamilton et al. 2022 iScience), hepatic AMPK activation (generic metformin ER), and CYP3A4 pharmacovigilance.
- [Nantucket Tick Radar](https://pocketgull.com/case-studies/nantucket-tick-radar): Vector-borne polymicrobial co-infection management (Lyme Borrelia, Babesia, Bartonella), Pretorius 2021 amyloid fibrin microclot grading, and Herxheimer pacing.
- [MS Neuro-Sanctuary](https://pocketgull.com/case-studies/neuro-sanctuary): Multiple Sclerosis demyelination, Uhthoff thermal conduction block management (0.5°C safety buffer), and 0.1 Hz vagal resonant biofeedback.
- [Darwin Vagal Enigma](https://pocketgull.com/case-studies/darwin-vagal-radar): Bayesian differential diagnosis (ME/CFS, POTS vs. Chagas disease), the 1872 "pneumo-gastric" reflex arc, and SFI complex dynamical systems attractors.
- [Curie Radium Marrow](https://pocketgull.com/case-studies/curie-radium-marrow): Aplastic anemia, ionizing radiation bone marrow failure, and hematopoiesis rescue.
- [Long COVID PEM Boundary](https://pocketgull.com/case-studies/long-covid-pem-boundary): Post-exertional malaise (PEM), endothelial microvascular hypoperfusion, and anaerobic threshold pacing.
- [Kahlo Central Sensitization](https://pocketgull.com/case-studies/kahlo-central-sensitization): Chronic spinal trauma, nociplastic pain amplification, and graded motor imagery.
- [OKN Grounding](https://pocketgull.com/case-studies/okn-grounding): Optokinetic nystagmus (OKN) stimulation, smooth-pursuit/saccadic eye tracking, and vestibulo-ocular grounding.
- [Sleep Architecture & Glymphatics](https://pocketgull.com/case-studies/sleep-architecture): Slow-wave N3 NREM sleep, Aquaporin-4 (AQP4) interstitial convective clearance, and delta wave (0.5–2 Hz) entrainment.

## Interoperability & APIs
- HL7 FHIR R4 API: `GET https://pocketgull.com/api/fhir/case-studies/:id` returns validated FHIR R4 Bundles containing Patient, Condition, Observation, and CarePlan resources with FDA 21 CFR Part 11 SHA-256 digital seals.
- Master Cohort Export: `GET https://pocketgull.com/api/fhir/case-studies/all`

## Clinical & Statutory Disclosures
- Non-Device Demarcation: PocketGull clinical decision support tools are for educational, research, and supportive self-management purposes only. They do not constitute an FDA-regulated medical device and do not replace professional medical judgment.
- Pharmacy Transparency: Recommendations contrast standard retail benchmarks ($150–$300/mo) against transparent $4–$10 generic retail benchmarks at Walmart, Kroger, Walgreens, and Amazon Pharmacy.
- FTC Affiliate Disclosure: As an Amazon Associate, PocketGull earns from qualifying purchases on non-prescription hardware and bibliotherapy recommendations.